ADRA-01

designed by adrafül labs inc.

a proprietary stack optimized for
mental clarity and cognitive
longevity.

ADRA-01

designed by adrafül labs inc.

a proprietary stack optimized for
mental clarity and cognitive
longevity.

[ formulation release ] december 2023

the first proprietary blend designed specifically for the productive class.

sustained energy

no crash

more focus

no jitters

more energy, less caffeine.

the first proprietary blend designed specifically for the productive class.

motivation & wakefulness

task-based cognitive enhancement

mental clarity

executive function

more energy, less caffeine.

motivation & wakefulness:

caffeine

[ C8H10N4O2 ]

+

l-theanine

[ C7H14N2O3 ]

increase motivation & alertness

we combine caffeine with l-theanine in a 1:2 ratio based on extensive literature that suggests a strong synergistic effect in boosting cognitive performance[1][2].

caffeine is an adenosine receptor antagonist (promoting wakefulness) and l-theanine has been documented to reduce the anxiety-related side-effects of caffeine.

mucuna pruriens  [ C9H11NO4 ]

increase dopamine availability

we combine caffeine with l-theanine in a 1:2 ratio based on extensive literature that suggests a strong synergistic effect in boosting cognitive performance.


caffeine is an adenosine receptor antagonist (promoting wakefulness) and l-theanine has been documented to reduce the anxiety-related side-effects of caffeine.

motivation & wakefulness:

caffeine

[ C8H10N4O2 ]

+

l-theanine

[ C7H14N2O3 ]

increase motivation & alertness

we combine caffeine with l-theanine in a 1:2 ratio based on extensive literature that suggests a strong synergistic effect in boosting cognitive performance[1][2].

caffeine is an adenosine receptor antagonist (promoting wakefulness) and l-theanine has been documented to reduce the anxiety-related side-effects of caffeine.

mucuna pruriens  [ C9H11NO4 ]

increase dopamine availability

we combine caffeine with l-theanine in a 1:2 ratio based on extensive literature that suggests a strong synergistic effect in boosting cognitive performance.


caffeine is an adenosine receptor antagonist (promoting wakefulness) and l-theanine has been documented to reduce the anxiety-related side-effects of caffeine.

task-based cognitive enhancement:

alpha-GPC  [ C8H20NO6P ]

stimulate acetylcholine production

α-GPC is a highly bioavailable form of choline[3], which can be used in the synthesis of acetylcholine and promote neurotransmission. α-GPC has been shown to lead to statistically significant improvements in learning and memory tasks[4] and may increase performance in other cognitively demanding tasks (like mental math[5] ) and in physical performance[6].

α-GPC provides a source for acetylcholine that downstream components of ADRA-01 exploit for out-of-sample improvements in cognitive performance.

uridine monophosphate  [ C9H13N2O9P ]

improve task-based cognitive function & verbal fluency

uridine is a naturally occurring (in the liver[7]) nucleotide base that acts as a monomer in RNA and is used to promote cellular membrane genesis. uridine’s involvement in the CDP-choline pathway leads to the formation of phosphatidylethanolamine, a phospholipid that plays a key role in neurotransmission[8]. we include UMP for its clear intellectual-

enhancing effects as well as its theorized ability to improve verbal fluency[9]. studies have shown that when taken in conjunction with a source of DHA and choline (provided by α-GPC), UMP can lead to significant cognitive enhancement in animals[10].

task-based cognitive enhancement:

alpha-GPC  [ C8H20NO6P ]

stimulate acetylcholine production

α-GPC is a highly bioavailable form of choline[3], which can be used in the synthesis of acetylcholine and promote neurotransmission. α-GPC has been shown to lead to statistically significant improvements in learning and memory tasks[4] and may increase performance in other cognitively demanding tasks (like mental math[5]) and in physical performance[6].

α-GPC provides a source for acetylcholine that downstream components of ADRA-01 exploit for out-of-sample improvements in cognitive performance.

uridine monophosphate  [ C9H13N2O9P ]

improve task-based cognitive function & verbal fluency

uridine is a naturally occurring (in the liver[7]) nucleotide base that acts as a monomer in RNA and is used to promote cellular membrane genesis. uridine’s involvement in the CDP-choline pathway leads to the formation of phosphatidylethanolamine, a phospholipid that plays a key role in neurotransmission[8]. we include UMP for its clear intellectual-

enhancing effects as well as its theorized ability to improve verbal fluency[9]. studies have shown that when taken in conjunction with a source of DHA and choline (provided by α-GPC), UMP can lead to significant cognitive enhancement in animals[10].

mental clarity:

PQQ  [ C14H6N2O8 ]

Pyrroloquinoline quinone is an antioxidant that supports mitochondrial biogenesis[11], which supports youthful cell function throughout the entire body. Research suggests that PQQ can increase attention, information processing, and short-term memory across various age groups[12][13]. Individuals over the age of 40 may experience even greater improvements in cognitive performance due to the natural decline in mitochondrial function that comes along with age.

We include PQQ for its attention-improving effects and ability to direct focus to particular tasks for extended periods of time.

mental clarity:

PQQ  [ C14H6N2O8 ]

Pyrroloquinoline quinone is an antioxidant that supports mitochondrial biogenesis[11], which supports youthful cell function throughout the entire body. Research suggests that PQQ can increase attention, information processing, and short-term memory across various age groups[12][13]. Individuals over the age of 40 may experience even greater improvements in cognitive performance due to the natural decline in mitochondrial function that comes along with age.

We include PQQ for its attention-improving effects and ability to direct focus to particular tasks for extended periods of time.

executive function:

agmatine  [ C5H14N4 ]

agmatine is most commonly used for its neuroprotective effects in treatments against central nervous system (CNS) disorders like Alzheimer’s Disease. however, we include it in ADRA-01 primarily because of its potential for activation of the alpha-2 adranergic receptor (α2A) which can inhibit the release of noradrenaline and improve metacognition[18].

executive function:

agmatine  [ C5H14N4 ]

agmatine is most commonly used for its neuroprotective effects in treatments against central nervous system (CNS) disorders like Alzheimer’s Disease. however, we include it in ADRA-01 primarily because of its potential for activation of the alpha-2 adranergic receptor (α2A) which can inhibit the release of noradrenaline and improve metacognition[18].

citations:

[1] Owen, G. N., Parnell, H., De Bruin, E. A., & Rycroft, J. A. (2008). The combined effects of L-theanine and caffeine on cognitive performance and mood. Nutritional neuroscience, 11(4), 193–198.

[2] Giesbrecht, T., Rycroft, J. A., Rowson, M. J., & De Bruin, E. A. (2010). The combination of L-theanine and caffeine improves cognitive performance and increases subjective alertness. Nutritional neuroscience, 13(6), 283–290.

[3] Abbiati, G., Fossati, T., Lachmann, G., Bergamaschi, M., & Castiglioni, C. (1993). Absorption, tissue distribution and excretion of radiolabelled compounds in rats after administration of [14C]-L-alpha-glycerylphosphorylcholine. European journal of drug metabolism and pharmacokinetics, 18(2), 173–180.

[4] Hoffman, J. R., Ratamess, N. A., Gonzalez, A., Beller, N. A., Hoffman, M. W., Olson, M., Purpura, M., & Jäger, R. (2010). The effects of acute and prolonged CRAM supplementation on reaction time and subjective measures of focus and alertness in healthy college students. Journal of the International Society of Sports Nutrition, 7, 39.

[5] Parker, A. G., Byars, A., Purpura, M., & Jäger, R. (2015). The effects of alpha-glycerylphosphorylcholine, caffeine or placebo on markers of mood, cognitive function, power, speed, and agility. Journal of the International Society of Sports Nutrition, 12(Suppl 1), P41.

[6] Ziegenfuss, T., Landis, J. & Hofheins, J. Acute supplementation with alpha-glycerylphosphorylcholine augments growth hormone response to, and peak force production during, resistance exercise. J Int Soc Sports Nutr 5 (Suppl 1), P15 (2008).

[7] Yamamoto, T., Koyama, H., Kurajoh, M., Shoji, T., Tsutsumi, Z., & Moriwaki, Y. (2011). Biochemistry of uridine in plasma. Clinica chimica acta; international journal of clinical chemistry, 412(19-20), 1712–1724.

[8] Gibellini, F., & Smith, T. K. (2010). The Kennedy pathway--De novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB life, 62(6), 414–428.

[9] Nootropics for Verbal Fluency. Nootropics Expert. (2023, October 29).

[10] Holguin, S. (1970, January 1). Consuming a diet enriched with choline, UMP, and DHA improves memory in rodents when these compounds increase phospholipids.

[11] Chowanadisai, W., Bauerly, K. A., Tchaparian, E., Wong, A., Cortopassi, G. A., & Rucker, R. B. (2010). Pyrroloquinoline quinone stimulates mitochondrial biogenesis through cAMP response element-binding protein phosphorylation and increased PGC-1alpha expression. The Journal of biological chemistry, 285(1), 142–152.

[12] Ikemoto, K. (2023, October 11). PQQ boosts brain function in older and younger generations. Research Features.

[13] M. Tamakoshi, T. Suzuki, E. Nishihara, S. Nakamura and K. Ikemoto, Food Funct., 2023, 14, 2496 DOI: 10.1039/D2FO01515C

[14] Ahmad M, Wolberg A, Kahwaji CI. Biochemistry, Electron Transport Chain. [Updated 2023 Sep 4]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-.

[15] Lautrup S, Sinclair D, Mattson M, Fang E. NAD+ in brain aging and neurodegenerative disorders. Cell Metab Rev. 2019;30(4):630-649.

[16] HIdo, Y., Chang, K., & Williamson, J. R. (2004). NADH augments blood flow in physiologically activated retina and visual cortex. Proceedings of the National Academy of Sciences of the United States of America, 101(2), 653–658.

[17] Liang M, Yin XL, Wang LY, et al. NAD+ attenuates bilirubin-induced hyperexcitation in the ventral cochlear nucleus by inhibiting excitatory neurotransmission and neuronal excitability. Front Cell Neurosci. 2017;11(1):21.

[18] Tobias U Hauser, Micah Allen, Nina Purg, Michael Moutoussis, Geraint Rees, Raymond J Dolan (2017) Noradrenaline blockade specifically enhances metacognitive performance eLife 6:e24901,

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